Mye-EUNITER
 

Botta, Bruno

Bruno Botta is full professor and he has been nominated Deputy Provst for the Internationalization  in November 2014. He is Head of the Dipartimento di Chimica e Tecnologie del Farmaco at Sapienza University of Rome since 2011. Since March, 16, 2015 he is Chair of the Cost Action CM-1407  "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery".  His interest during the years has been focused on the structural elucidation and synthesis of biologically active compounds derived from living plants. Since 20 years, he has been working on the field of plant tissue cultures in combination with chemistry directed toward the understanding of biosynthetic pathways of the compounds under investigation. During the years, some plant enzymes (such as those belonging to the peroxidases family) derived from the above-mentioned cell cultures have been isolated and purified and some kinetic studies have been performed too. During the last 15 years, Prof. Botta focused his attention also on both the synthesis and host-guest studies of artificial receptors of the resorcarenes family.

During the last 7 years  he focused his attention on the Hedgehog (Hh) signalling pathway which plays a pivotal role in the initiation, proliferation, invasion and metastasis of various cancers (inter alia medulloblastoma).

He is author of 135 publications, including 6 patents (3 national and 3 international – USA and Europe), and, besides that, he is author and co-author of 10 books. For the Italian publishing house Edi-Ermes he edited 2 text books of Organic Chemistry.

Models available:

Chemistry of natural products: isolation and synthesis; anticancer and HIV; stem cells studies finalized at the inhibition of Hedgehog pathway

Cells available:

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Technology available:

The expectation is to cooperate in a multidisciplinary group in order to provide our know-how on the chemistry of natural products, in order to try to supply using our own natural products for biological tests both in vitro and in vivo. Moreover we have our own collection of 1000 natural products, both synthetic and derived from higher plants.

Key publications related to Mye-EUNITER:

  1. D'Acquarica, I., Calcaterra, A., Sacco, F., Balzano, F., Aiello, F., Tafi, A., Pesci, N., Uccello-Barretta, G., Botta, B., Stereochemical preference of 2'-deoxycytidine for chiral bis(diamido)-bridged basket resorcin[4]arenes, (2013) Chirality, 25 (12), pp. 840-851.

  2. Ghirga, F., D'Acquarica, I., Delle Monache, G., Toscano, S., Mannina, L., Sobolev, A.P., Ugozzoli, F., Crocco, D., Antiochia, R., Botta, B., Undecenyl resorc[4]arene in the chair conformation as preorganized synthon for olefin metathesis (2013) RSC Advances, 3 (38), pp. 17567-17576.

  3. Mascarello, A., Mori, M., Chiaradia-Delatorre, L.D., Menegatti, A.C.O., delle Monache, F., Ferrari, F., Yunes, R.A., Nunes, R.J., Terenzi, H., Botta, B., Botta, M. Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B: Inhibitors from Natural Products (2013) PLoS ONE, 8 (10), art. no. e77081

  4. Ghirga, F., D'Acquarica, I., Delle Monache, G., Mannina, L., Molinaro, C., Nevola, L., Sobolev, A.P., Pierini, M., Botta, B., Reaction of nitrosonium cation with resorc[4]arenes activated by supramolecular control: Covalent bond formation (2013) Journal of Organic Chemistry, 78 (14), pp. 6935-6946.

  5. Friggeri, L., Scipione, L., Costi, R., Kaiser, M., Moraca, F., Zamperini, C., Botta, B., Di Santo, R., De Vita, D., Brun, R., Tortorella, S. New promising compounds with in vitro nanomolar activity against Trypanosoma cruzi (2013) ACS Medicinal Chemistry Letters, 4 (6), pp. 538-541.

Contact details:

Sapienza Università di Roma
piazzale aldo moro, 5
00185 Rome
Italy
Tel. +390649912781
Fax +390649912780
bruno.botta@uniroma1.it