Mye-EUNITER
 

Brandau, Sven

Sven´s main research area is the immunological tumour-host interaction with a focus on myeloid cells. Additional research projects aim at developing novel immunotherapies for head and neck cancer and investigating the role of mesenchymal stromal cells in cancer and infection.

Models available:

  • Head and neck cancer
  • Murine orthotopic syngeneic + human xenograft models
  • Human samples (blood, tissue)
  • Patient data base incl follow-up data

Cells available:

  • Neutrophils
  • Myeloid-derived-suppressor cells

Technology available:

  • Flow cytometry (up to 8-color)
  • AMNIS, IVIS imaging, 2-photon IVM
  • Cellular immunology
  • Immunohistochemistry, tissue microarrays
  • Luminex

Key publications related to Mye-EUNITER:

  1. Suttmann H, Riemensberger J, Bentien G, Schmaltz D, Stöckle M, Jocham D, Böhle A, Brandau S. (2006) Neutrophil granulocytes are required for effective BCG-immunotherapy of bladder cancer and orchestrate local immune responses. Cancer Res 66 (16), 8250-8257

  2. Davey MS, Tamassia N, Rossato M, Bazzoni F, Calzetti F, Bruderek K, Sironi M, Zimmer L, Bottazzi B, Mantovani A, Brandau S, Moser B, Eberl M, Cassatella MA. (2011) Failure to detect production of IL-10 by activated human neutrophils. Nat Immunol. (correspondence) 12(11):1017-8.

  3. Brandau S, Trellakis S, Bruderek K, Schmaltz D, Steller G, Elian M, Suttmann H, Schenck M, Welling J, Zabel P, Lang S. (2011) Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties. J Leukoc Biol. 89(2), 311-317

  4. Trellakis S, Bruderek K, Hütte J, Elian, M, Hoffmann TK, Lang S, Brandau S. (2013) Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancer  Innate Immunity 19 (3), 328-336

  5. Brandau S, Moses K, Lang S. The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: Cousins, siblings or twins? (2013) Semin Cancer Biol. 23 (3), 171-182

Contact details:

Department of Otorhinolaryngology
Research Division
Universitätsklinikum Essen
University of Duisburg-Essen
Hufelandstrasse 55
45122 Essen
Germany
Tel.: +49 201 / 723-3193
Fax: +49 201 / 723-5196
E-mail: Sven.Brandau@uk-essen.de

Researcher Spotlight:

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Sven Brandau studied Biology in Hamburg and Los Angeles and conducted his PhD studies from 1993 until 1996 at the Bernhard-Nocht Institute for Tropical Medicine in Hamburg. From 1996 until 2007 he worked as a postdoctoral fellow and later as a senior scientist and independent group leader at the Research Center Borstel. During his habilitation period he started focusing on cancer immunotherapy and obtained his venia legendi in Immunology and Cell Biology at the University of Lübeck in 2003. In 2007 he moved to the University of Duisburg-Essen where he became an associate professor in 2009.

Sven is the head of the Experimental Research Division of the Department of Otorhinolarnygology, University Hospital Essen, and co-chairman of the BIOME graduate school. He has received several awards for his work on experimental and translational aspects of tumour immunology.

Sven´s main research area is the immunological tumour-host interaction with a focus on myeloid cells. Additional research projects aim at developing novel immunotherapies for head and neck cancer and investigating the role of mesenchymal stromal cells in cancer and infection.

Sven has two active roles in Mye-EUNITER: he is the Action Chair and one of the working group leaders of WG 2 which focuses on the functional and molecular analysis of MRCs.