Mye-EUNITER
 

Cuturi, Maria Cristina

Models available:

  • Dendritic cell immunobiology
  • Antigen presentation and recognition
  • Immunoregulatory mechanisms
  • Pre-clinical models of transplantation and immunoregulation in mouse, humanized mice rat and monkey
  • Human tolerogenic dendritic cell
  • Human protocol of cell therapy in kidney recipients
  • New molecules and mechanisms of immunoregulation

Cells available:

  • Tolerogenic DC
  • MDSC
  • Treg

Technology available:

  • We are doing research in mouse, rat, monkey and man
  • Animal models of transplantation, of autoimmunity and inflammation
  • Clinical protocol (Phase I/II) ongoing
  • Flow cytometric phenotyping, cell sorting
  • Cellular immunology gene expression
  • Immunohistochemistry

Key publications related to Mye-EUNITER:

  1. Segovia M, Louvet C, Charnet P, Savina A, Tilly G, Gautreau L, Carretero-Iglesia L, Beriou G, Cebrian I, Cens T, Hepburn L, Chiffoleau E, Floto RA, Anegon I, Amigorena S, Hill M, Cuturi MC. Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation. Am J Transplant. 2014 May;14(5):1021-31.

  2. Drujont L, Carretero-Iglesia L, Bouchet-Delbos L, Beriou G, Merieau E, Hill M, Delneste Y, Cuturi MC, Louvet C. Evaluation of the therapeutic potential of bone marrow-derived myeloid suppressor cell (MDSC) adoptive transfer in mouse models of autoimmunity and allograft rejection.  PLoS One. 2014 Jun 13;9(6):e100013.

  3. Hill M, Thebault P, Segovia M, Louvet C, Bériou G, Tilly G, Merieau E, Anegon I, Chiffoleau E, Cuturi MC. Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferon-gamma and epstein-barr virus-induced gene 3. Am J Transplant. 2011 Oct;11(10):2036-45.

  4. Moreau A, Hill M, Thébault P, Deschamps JY, Chiffoleau E, Chauveau C, Moullier P, Anegon I, Alliot-Licht B, Cuturi MC. Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates. FASEB J. 2009 Sep;23(9):3070-7.

  5. De Wilde V, Van Rompaey N, Hill M, Lebrun JF, Lemaître P, Lhommé F, Kubjak C, Vokaer B, Oldenhove G, Charbonnier LM, Cuturi MC, Goldman M, Le Moine A. Endotoxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1. Am J Transplant. 2009 Sep;9(9):2034-47.

  6. Chabannes D, Hill M, Merieau E, Rossignol J, Brion R, Soulillou JP, Anegon I, Cuturi MC. A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood. 2007 Nov 15;110(10):3691-4.

  7. Baas MC, Kuhn C, Valette F, Mangez C, Duarte MS, Hill M, Besançon A, Chatenoud L, Cuturi MC, You S. Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet allograft acceptance. J Immunol. 2014 Nov 1;193(9):4696-703.

  8. Delneste Y, Gregoire M, Cuturi MC, Anegon I. Yin Yang of immunoregulation in organ transplantation and cancer. Immunotherapy. 2011 Apr;3(4 Suppl):1-3. doi: 10.2217/imt.11.54. PubMed PMID: 21524157.

Contact details:

INSERM UMR 1064 - Center for Research in Transplantation and Immunology
(www.itun.nantes.inserm.fr)
CHU de Nantes.
30, boulevard Jean Monnet.
44093 Nantes France
Tel secretary.  33(0)2 40 08 74 10
Tel office.     33(0)2 40 08 78 41
Maria-Cristina.Cuturi@univ-nantes.fr