Delputte, Peter

Models available:

Sialoadhesin, macrophage, polarization, Respiratory Syncytial Virus (RSV), immunotherapy, regulatory cells, lung, siglec, CD169, S. pneumoniae, Leishmania, pathogen-macrophage interactions,  pathogen-triggered immune-cell mediated pathology,

Technology available:

Recombinant antibodies, antibody-fusion constructs, macrophage-targeted delivery, hybridoma development, L3 facility, A2 animal infectious unit.

Key publications related to Mye-EUNITER:

  1. Delputte PL, Van Gorp H, Favoreel HW, Hoebeke I, Delrue I, Dewerchin H, Verdonck F, Verhasselt B, Cox E, Nauwynck HJ. (2011). Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages. PLoS One. 6(2):e16827.

  2. Ooms K, Van Gorp H, Van Gaever T, Nauwynck HJ, Delputte PL. (2013). Development of a recombinant antibody to target peptides and proteins to sialoadhesin-expressing macrophages. BMC Biotechnol. 13:33. doi: 10.1186/1472-6750-13-33.

  3. Van Gorp H., and [Delputte P.L. - Nauwynck H.J.] (2010). Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy. Molecular Immunology. ePub March 16.

  4. De Baere MI, Van Gorp H, Nauwynck HJ, Delputte PL. (2011).Antibody binding to porcine sialoadhesin reduces phagocytic capacity without affecting other macrophage effector functions. Cell Immunol. 271(2):462-73.

  5. Van Breedam W., Van Gorp H., Zang J., Crocker P.R. and [Delputte P.L. - Nauwynck H.J.] (2009). The M/GP5 Glycoprotein Complex of Porcine Reproductive and Respiratory Syndrome Virus Binds the Sialoadhesin Receptor in a Sialic Acid-Dependent Manner. Plos Pathogens. 15;6(1):e1000730.