Dittmer, Ulf

Ulf’s research focuses on the basic cellular and molecular mechanisms of immunity against retroviruses as well as vaccine development against retroviruses. He is also interested in immunotherapy against retroviral infections and virus-induced cancer, persistent viral infections and retrovirus-induced immunosuppression.

Models available:

  • Retroviral infection, chronic infections, mouse models
  • Animal model: Friend retroviral infection of mice.
  • CMV and HBV infection of mice.

Cells available:

  • Regulatory T cells, dendritic cells, MDSCs, effector T cells

Technology available:

  • Flow cytometry (up to 13-colours).
  • Isolation of different populations of immune cells and in vitro functional characterisation.
  • In vivo and in vitro analysis of immunomodulatory factors directed at antigen-specific T cells.
  • In vivo analysis of antigen-specific cellular cytotoxicity of T cells.

Key publications related to Mye-EUNITER:

  1. Zelinskyy G, Dietze KK, Hüsecken YP, Schimmer S, Nair S, Werner T, Gibbert K, Kershaw O, Gruber AD, Sparwasser T, Dittmer U. The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood. 2009 Oct 8;114(15):3199-207.

  2. Dietze KK, Zelinskyy G, Gibbert K, Schimmer S, Francois S, Myers L, Sparwasser T, Hasenkrug KJ, Dittmer U. Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2420-5.

  3. Kathrin Gibbert, Jara J. Joedicke, Andreas Meryk, Mirko Trilling , Sandra Francois, Janine Duppach, Anke Kraft, Karl S. Lang and Ulf Dittmer. Interferon alpha subtype 11 activates NK cells and enables control of retroviral infection. 2012 Plos Pathogens, Epub ahead.