Dorhoi, Anca

Research interests focus on innate immunity in bacterial lung infections, particularly tuberculosis (TB). Current projects address i) identification of novel pathways which control inflammation and ii) design of host directed interventions.

Models available:

  • Mouse models of TB and other bacterial pneumonias (P. aeruginosa, S. pneumoniae). Ex vivo models to study macrophage and neutrophil immunobiology.

Cells available:

  • Macrophages, neutrophils, MDSCs.

Technology available:

  • Flow cytometry, Sorting (FACS, MACS), Immunohistochemistry, Immunocytochemistry, NGS, Microarrays, Fluidigm,  ArrayScan HCA, Luminex, Cellular immunology, Microbiological assays

Key publications related to Mye-EUNITER:

  1. Knaul J., Jörg S., Oberbeck-Mueller D., Heinemann E., Scheuermann L., BrinkmannV., Mollenkopf H.J., Yeremeev Y., Kaufmann S.H., Dorhoi A. 2014. Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis. Am J Respir Crit Care Med. 1;190(9):1053-66.
  2. Dorhoi A., Yeremeev V., Nouailles G., Weiner J. 3rd, Jörg S., Heinemann E., Oberbeck-Müller D., Knaul J.K., Vogelzang A., Reece S.T., Hanke K., Mollenkopf H.J., Brinkmann V., Kaufmann S.H. 2014. Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics. Eur J Immunol. 2014 Aug;44(8):2380-93
  3. Dorhoi A., Iannaccone M., Maertzdorf J., Nouailles G., Weiner J. 3rd, Kaufmann S.H. 2014. Reverse Translation in Tuberculosis: Neutrophils Provide Clues for Understanding Development of Active Disease. Front Immunol. 5;5:36.
  4. Nouailles G., Dorhoi A., Koch M., Zerrahn J., Weiner J.. 3rd, Faé K.C., Arrey F., Kuhlmann S., Bandermann S., Loewe D., Mollenkopf H.J., Vogelzang A., Meyer-Schwesinger C., Mittrücker H.W., McEwen G., Kaufmann S.H. 2014. CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis. J Clin Invest. 3;124(3):1268-82.
  5. Dorhoi A., Iannaccone M., Farinacci M., Faé K.C., Schreiber J., Moura-Alves P., Nouailles G., Mollenkopf H.J., Oberbeck-Mueller D., Jörg S., Heinemann E., Hahnke K., Löwe D., Del Nonno F., Goletti D., Capparelli R., Kaufmann S.H. 2013. MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment. J Clin Invest. 2013 Nov 1;123(11):4836-48.

Contact details:

Max Planck Institute for Infection Biology
Department of Immunology
Tel.: +49/30-28460-510