Mye-EUNITER
 

Esendagli, Gunes

Cells and models available:

Breast cancer (mouse, rat, human)

Lung cancer (mouse, human)

Pancreatic cancer (mouse)

Colorectal cancer (human)

Granulocytic myeloid-derived suppressor cells (MDSCs)

Monocytic MDSCs

 

Key scientific question relevant to Mye-EUNITER:

Identification of accurate and specific surface markers for MDSCs in human cancers, especially colorectal and breast cancers.

May transcript variants (and therefore protein isoforms) of the cell surface molecules associated with human MDSC immune-phenotype serve as specific markers?

Techniques available:

Flow cytometry

Fluorescence activated cell sorting (FACS)

RT-PCR

ELISA

Cell culture

Selected publications related to Mye EUNITER

  1. Dolen Y, Esendagli G. Myeloid leukemia cells with a B7-2(+) subpopulation provoke Th-cell responses and become immuno-suppressive through the modulation of B7 ligands. Eur J Immunol. 2013 Mar;43(3):747-57. doi: 10.1002/eji.201242814. Epub 2013 Jan 31. PubMed PMID: 23175469.
  2. Karasar P, Esendagli G. T helper responses are maintained by basal-like breast cancer cells and confer to immune modulation via upregulation of PD-1 ligands. Breast Cancer Res Treat. 2014 Jun;145(3):605-14. doi: 10.1007/s10549-014-2984-9. Epub 2014 May 10. PubMed PMID: 24816762.
  3. Rama-Esendagli D, Esendagli G, Yilmaz G, Guc D. Spheroid formation and invasion capacity are differentially influenced by co-cultures of fibroblast and macrophage cells in breast cancer. Mol Biol Rep. 2014 May;41(5):2885-92. doi: 10.1007/s11033-014-3144-3. Epub 2014 Jan 28. PubMed PMID: 24469725.
  4. Dolen Y, Gunaydin G, Esendagli G, Guc D. Granulocytic subset of myeloid derived suppressor cells in rats with mammary carcinoma. Cell Immunol. 2015 May;295(1):29-35. doi: 10.1016/j.cellimm.2015.02.005. Epub 2015 Feb 18. PubMed PMID: 25732602.
  5. Esendagli G, Bruderek K, Goldmann T, Busche A, Branscheid D, Vollmer E, Brandau S. Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer. Lung Cancer. 2008 Jan;59(1):32-40. Epub 2007 Sep 7. PubMed PMID:17825949.

 

Contact details:

Hacettepe University Cancer Institute

Department of Basic Oncology, Division of Tumor Biology and Immunology

06100, Sihhiye, Ankara - Turkey

Telephone: +90 312 305 44 13

Email: gunese@hacettepe.edu.t

gunes.esendagli@lycos.com