Fleischhauer, Katharina

Katharina´s scientific interests are focused on translational research aimed at unravelling the biological mechanisms underlying the clinical success or failure of transplantation, with particular regards to hematopoietic stem cell transplantation. This includes the characterisation of cellular and humoral alloreactivity and its role in transplantation, as well as the molecular and functional polymorphism of the HLA system and immune-related genes.

Key publications related to Mye-EUNITER:

  1. Fleischhauer K, Shaw BE, Gooley T, Malkki M, Bardy P, Bignon JD, Dubois V, Horowitz MM,  Madrigal JA, Morishima Y, Oudshoorn M, Ringden O, Spellman S, Velardi A, Zino E, Petersdorf EW. Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated donor haemopoietic-cell transplantation: a retrospective study. Lancet Oncol 2012: 13: 366-374.  Epub 2011 Feb 14.

  2. Toffalori C, Cavattoni I, Deola S, Mastaglio S, Giglio F, Mazzi B, Assanelli A, Peccatori J, Bordignon C, Bonini C, Cortelazzo S, Ciceri F, Fleischhauer K, Vago L. Genomic loss of patient-specific HLA in acute myeloid leukemia relapse after well-matched unrelated donor HSCT [letter]. Blood 2012: 119: 4813-4815.

  3. Sizzano F, Zito L, Crivello P, Crocchiolo R, Vago L, Zino E, Fleischhauer K. Significantly higher  frequencies of alloreactive CD4+ T cells responding to non-permissive than to permissive HLADPB1 T cell epitope disparities. Blood 2010: 116: 1991-1992.

  4. Marktel S*, Napolitano S, Zino E, Cappelli B, Chiesa R, Poli F, Crocchiolo R, Ronchi P, Rossini S, Ciceri F, Roncarolo MG, Fleischhauer K. Platelet transfusion refractoriness in highly immunized beta thalassemia children undergoing stem cell transplantation. Pediatr Transplant 2010: 14: 393-401. Epub 2010 Jan 7.

  5. Vago L, Perna SK, Zanussi M, Mazzi B, Barlassina C, Lupo Stanghellini MT, Perrelli NF, Cosentino C, Torri F, Angius A, Forno B, Casucci M, Bernardi M, Peccatori J, Corti C, Bondanza A, Ferrari M, Rossini S, Roncarolo MG, Bordignon C, Bonini C, Ciceri F, Fleischhauer K. Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med 2009: 361: 478- 488.

Contact details:

Institute for Experimental Cellular Therapy
University of Duisburg-Essen
Hufelandstrasse 55
45122 Essen
Tel.: +49 201 723 4583
Fax: +49 201 723 4546