Mye-EUNITER
 

Król, Magdalena

Main current research topics focus on: novel targeted drug delivery systems to the tumor; interactions between macrophages and cancer cells and their involvement in WNT signalling; role of IL-28 in cancer angiogenesis; molecular interactions between cancer stem cells and tumor-associated macrophages; miRNA expression profiling of metastatic canine mammary cancer.

Models available:

  • Breast cancer, mammary cancer (canine and mouse), MDSC, macropahges, tumor-associated macrophages

Cells available:

  • Cancer cell lines (human, mouse, canine) and tumor-derived primary cell lines, cancer stem cells, endothelial cells, blood-isolated MDSC and blood either bone-marrow isolated macrophages

Technology available:

  • Microarray (mRNA and miRNA) scanner and analysis platform, real time PCR device, animal facility, cell culture lab, confocal microscopy, FACS

Key publications related to Mye-EUNITER:

  1. Mucha J, Majchrzak K, Taciak B, Hellmen E, Król M (2014) MDSCs Mediate Angiogenesis and Predispose Canine Mammary Tumor Cells for Metastasis via IL-28/IL-28RA (IFN-λ) Signaling, PLoS ONE, 9(7):e103249

  2. Winiarska M, Bojarczuk K, Pyrzynska B, Bil J, Siernicka M, Dwojak M, Bobrowicz M, Miazek N, Zapala P, Zagozdzon A, Krol M, Syta A, Podszywalow- Bartnicka P, Pilch Z, Dabrowska- Iwanicka A, Juszczynski P, Efremov D, Slabicki M, Zenz T, Le Roy A, Olive D, Rygiel T, Leusen JHW, Golab J (2014) Inhibitors of SRC kinases impair antitumor activity of anti- CD20 monoclonal antibodies, mAbs; 6(5)

  3. Król M, Mucha J, Majchrzak K, Homa A, Bulkowska M, Majewska A, Gajewska M, Pietrzak M, Perszko M, Romanowska K, Pawłowski K, Manuali E, Hellmen E, Motyl T (2014) Macrophages Mediate a Switch between Canonical and Non-Canonical Wnt Pathways in Canine Mammary Tumors, PLoS ONE, 9(1):e83995 

  4. Majchrzak K, Lo Re D, Gajewska M, Bulkowska M, Homa A, Pawłowski K, Motyl T, Murphy PV, Król M (2013) Migrastatin Analogues Inhibit Canine Mammary Cancer Cell Migration and Invasion, PLoS ONE, 8(10): e76789

  5. Król M, Majchrzak K, Jakubowska A, Karwicka M, Pawłowski K, Mucha J, Motyl T (2013) CSF-1R as an inhibitor of apoptosis and promotor of proliferation, migration and invasion of canine mammary cancer cells, BMC Veterinary Research, 9:65

Contact details:

Warsaw University of Life Sciences
Nowoursynowska 159
02-787 Warsaw
Poland
Tel. +48225936280
Fax +48228472452
magdalena_krol@sggw.pl
www.krol-lab.sggw.pl