Ludwig, Stephan

Models available:

  • Influenza virus, virus-host cell interaction, innate immune response (murine model)

Cells available:

  • Monocytic cells
  • Epithelial cells
  • Endothelial cells
  • Neutrophils
  • NK cells

Technology available:

  • Flow cytometry
  • Mouse infections and analysis under BSL2 and 3 conditions
  • Reverse genetics technology
  • Mouse monitoring system
  • Immunofluorescence imaging,
  • Cellular immunology
  • Immunohistochemistry

Key publications related to Mye-EUNITER:

  1. Köther K, Nordhoff C, Masemann D, Varga G, Bream JH, Gaestel M, Wixler V, Ludwig S. (2014) MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection. FASEB J. Oct;28(10):4235-46.

  2. Börgeling, Y., Schmolke, M., Viemann, D., Nordhoff, C., Roth, J., and Ludwig S. (2014) Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protect Mice from Lethal H5N1 Infection. Journal of Biological Chemistry 289, 13-27.

  3. Khoufache, K; Nacken, W; Vogel, A; Delenne, M; Carmeliet, P; Lina, B; Rimmelzwaan, G.F; Planz, O; Ludwig, S; Riteau, B (2013) Protease-Activated-Receptor-1 is a critical host pathogenicity factor for influenza A virus infections in mice. J Clin Invest 123, 206-214.

  4. Schmolke, M., Viemann, D., Roth, J., and Ludwig, S. (2009) Essential impact of NF-κB signaling on the H5N1 influenza A virus-induced transcriptome. Journal of Immunology 183, 5180-5189

  5. Feld, M., V. M. Shpacovitch, C. Ehrhardt, C. Kerkhoff, M. D. Hollenberg, N. Vergnolle, S. Ludwig, and M. Steinhoff (2008) Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. J Immunol 180:6903-6910.