Mye-EUNITER
 

Mills, Kingston

Models available:

  • Animal models of autoimmunity (EAE, colitis), cancer (B16 melanoma, CT26) and infection (Bordetella pertussis and Fasciola hepatica)

Cells available:

  • CD4 T cell subtypes, innate driving adaptive immunity, immunity to infection,

Technology available:

  • Phenotying and functional assays for M1/M2 macrophages, tolerogenic DCs, innate lymphoid cells (ILC2, ILC3), gamma delta T cells. Effects of T cell subtypes (Th1/Th2/ Th17/Tregs) responses  

Key publications related to Mye-EUNITER:

  1. Sutton, CE. Lalor, SJ, Sweeney, C, Brereton, C, Lavelle, E.C. and  Mills, K.H.G.  (2009) IL-1β and IL-23 promote innate IL-17 production by gd T cells which amplifies Th17 responses and autoimmunity Immunity 31(2):331-41.

  2. Mills, K.H.G. (2011) TLR-dependant T cell activation in autoimmunity. Nature Rev. Immunol. 11(12): 807-22.

  3. Jones, S. A., Sutton, C. E., Cua, D., Mills, K. H. (2012) Therapeutic potential of targeting IL-17.  Nature Immunol 13, 1022-5.

Contact details:

Trinity Biomedical Sciences Institute
Trinity College Dublin
152-160 Pearse St
2 Dublin
Ireland
Tel. +35318963573
kingston.mills@tcd.ie