O’Neill, Sandra

Research interests focus on understanding the mechanisms that occur in pathogen co-infections and the interactions between infectious and non-communicable diseases. In particular understanding how helminth infections increase the susceptibility to infectious diseases such as tuberculosis, HIV and malaria while preventing the initiation and perpetuation of autoimmunity. The major focus of our investigation is to identify novel helminth molecules or pathways that are involved in the suppression of Th1/Th17 pathways. These studies will enable scientist to further understand mechanisms of immune-modulation by helminth parasites and identify molecules and/or pathways that could be exploited as novel therapeutics for autoimmune diseases. In addition, we wish to exploit these molecules as important diagnostic markers, novel vaccine candidates or as biomarkers in the control of helminth infection in human and animal populations.

Key publications related to Mye-EUNITER:

  1. LaCourse EJ, Perally S, Morphew RM, Moxon JV, Prescott M, Dowling DJ, O'Neill SM, Kipar A, Hetzel U, Hoey E, Zafra R, Buffoni L, Pérez Arévalo J, Brophy PM.. 2012. The Sigma class glutathione transferase from the liver fluke Fasciola hepatica.. 6, 5, ppe1666-.

  2. Morphew RM, Hamilton CM, Wright HA, Dowling DJ, O'Neill SM, Brophy PM.. 2012. Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40.

  3. Vukman KV, Visnovitz T, Adams PN, Metz M, Maurer M, O'Neill SM. 2012. Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation. 61, 1, pp79-85.

  4. Jackson AL, Asaolu SO, Molloy SF, Abiona TC, Bruce MC, Ranford-Cartwright L, O'Neill SM, Holland CV and Kirwan P. 2010. Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial. Bmc Infectious Diseases, 10, , pp277-282.