Roussel, Mikael

Models available:

Human samples (blood, bone marrow, tumors); B-cell lymphomas or healthy donors; clinical data and follow-up.

Cells available:

Human macrophages, MDSCs. Added value of CyTOF analysis on the MRC compartment in normal tissues and lymphomas.

Technology available:

Fluorescent flow cytometry (Beckman Coulter: Navios, Cytoflex. BD: LSRFortessa X20)
Mass cytometry (CyTOF)
High-dimensional analysis (SPADE, viSNE)
Cell sorting

Key publications related to Mye-EUNITER:

  1. Gros A*, Roussel M*, Sauvadet E, Gacouin A, Marqué S, Chimot L, Lavoué S, Camus C, Fest T, Le Tulzo Y. The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients. Intensive Care Med 2012;38:445–452. *equal contribution

  2. Roussel M, Gros A, Gacouin A, Le Meur N, Le Tulzo Y, Fest T. Toward new insights on the white blood cell differential by flow cytometry: A proof of concept study on the sepsis model. Cytometry B Clin Cytom 2012;82:345–352.

  3. Roussel M, Gros A, Sauvadet E, Gacouin A, Marqué S, Chimot L, Lavoué S, Camus C, Fest T, Le Tulzo Y. CD64, a Reliable Biomarker of Bacterial Infection in Intensive Care Units? AJRCCM 2012c;186:1058-1059.

  4. Azzaoui I, Uhel F, Rossille D, Pangault C, Dulong J, Le Priol J, Lamy T, Houot R, Le Gouill S, Cartron G, Godmer P, Bouabdallah K, Milpied N, Tarte K, Fest T, Roussel M. T-cell defect in Diffuse Large B-cell Lymphomas involves expansion of myeloid derived suppressor cells expressing IL-10, PD-L1 and S100A12. Blood 2016 (in press : DOI 10.1182/blood-2015-08-662783).