Santibañez, Juan Francisco

Models available:

  • Mouse skin cancer.
  • Endothelial cells. Mesenchymal stem cells. Macrophages cell lines (RAW 264.7, THP1)

Cells available:

  • Macrophages

Technology available:

  • Flow cytometry
  • immunofluorescence assays (IF, cell tracking)
  • Signal transduction by specifics luciferase reporters (MAPK, NFkB, Smads)

Key publications related to Mye-EUNITER:

  1. Mojsilović S and Santibanez JF. Transforming growth factor-beta differently regulates urokinase type plasminogen activator and matrix metalloproteinase-9 expression in mouse macrophages; analysis of intracellular signal transduction. (Submitted, 2014)

  2. Kristic J and Santibanez JF. Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells. ScientificWorldJournal. 2014 Jan 21;2014:521754. doi: 10.1155/2014/521754.

  3. Kocic J, Bugarski D, Santibanez JF. SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes. Eur J Cancer. 2012 Jul;48(10):1550-7