Sohrabi, Yahya


Human and mouse models of  leishmaniasis, mouse models to study genetic susceptibility to infection diseases and cancer, in vitro models for drug development.

Major cell types studied:

T cells, macrophages, BMDM, peritoneal macrophages, neutrophils, eosinophils 

Technology used:

Flow cytometry, FACS-sorting, DNA, RNA isolation and purification, DNA and RNA array,  Immunohistochemistry, histology, cell isolation and analysis, cell culture, cytokine and chemokine assay. 

Key publications related to Mye-EUNITER:

Sohrab, Y., Havelkova, H., Kobets, T., Sima M. Volkova, V. Grekov, I., Jarošíková, T., chicken, I., Vojtíšková, J., Svobodová, M., Demant, P., Lipoldová, M. Mapping the Susceptibility Genes for and Response to Leishmania tropica in Mouse (2013) PLoS Neglected Tropical Diseases, 7 (7), art. no. e2282.

Khamesipour, A., Nateghi Rostami, M., Tasbihi, M., Miramin Mohammadi, A., Shahrestani, T., Sarrafnejad, A., Sohrabi, Y., Eskandari, SE, Keshavarz Valian, H. Phenotyping of circulating CD8 + T cell subsets in human cutaneous leishmaniasis (2012) microbes and infectious, 14 (9), pp. 702-711.

Kobets, T., Havelkova, H., Grekov, I., Volkova, V., Vojtíšková, J., Slapničková, M., chicken, I., Sohrab, Y., Svobodová, M., Demant, P., Lipoldová, M.Genetics of host response to Leishmania tropica in mice - control of different skin pathology, chemokine Reaction, and invasion into spleen and liver (2012) PLoS Neglected Tropical Diseases, 6 (6), art. no. e1667.

Lipoldová, M., Havelková, H., Badalová, J., Vojtíšková, J., Quan, L., Krulová, M., Sohrabi, Y., Stassen, A.P., Demant, P. Loci controlling lymphocyte production of interferon γ after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility (2010) Cancer Immunology, Immunotherapy, 59 (2), pp. 203-213.