Stratmann, Thomas

Models available:

  • Type 1 Diabetes
  • Dendritic cells
  • Targeted lysosomal antigen delivery
  • Immunotherapy

Cells available:

  • Macrophages/ DCs
  • T and B cell hybridomas, primary T cell cultures

Technology available:

Relevant functional assays:

  • Flow cytometry and cell sorting, islet isolation, adoptive cell transfer, T/B cell activation and ELISPOT, ELISA, phage display - B cell epitope analysis, MHC tetramer generation + other recombinant molecules

Animal models:

  • Mouse, TCR Tg models, Foxp3.EGFP Knockin, NOD.SCID

Disease models:

  • Type 1 Diabetes - NOD mouse

Key publications related to Mye-EUNITER:

  1. Presa M, Ortiz AZ, Garabatos N, Izquierdo C, Rivas EI, Teyton L, Mora C, Serreze D, Stratmann T. Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice. Eur J Immunol. 2013;43:2969-79. IF=4.97.

  2. Rivas EI, Driver JP, Garabatos N, Presa M, Mora C, Rodriguez F, Serreze DV, Stratmann T. Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse. J Immunol. 2011;186:4078-87. IF: 5.78.

  3. Wen L, Green EA, Stratmann T, Panosa A, Gomis R, Eynon EE, Flavell RA, Mezquita JA, Mora C. In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18. Eur J Immunol. 2011;41:1344-51. IF: 5.1.