Thor Straten, Per

Research interests focus on impact of innate cells (and cancer cells) on various aspects of anti-cancer T cell responses.

Models available:

  • Human setting: melanoma, prostate cancer, ovarian cancer, renal cell carcinoma, hematological malignancies
  • Mouse models: syngeneic B16 melanoma, humanized mouse models; scid and NSG.

Technology available:

  • Flow cytometry, T-cell cloning, Functional T-cell assays, co-culture assays, Transfection and transduction of T cells, use of humanized mouse models for adoptive cell transfer studies

Key publications related to Mye-EUNITER:

  1. Andersen, R. S., P. Kvistborg, T. M. Frosig, N. W. Pedersen, R. Lyngaa, A. H. Bakker, C. J. Shu, P. thor Straten, T. N. Schumacher, and S. R. Hadrup. 2012. Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers. Nat. Protoc. 7: 891-902.

  2. Becker, J. C., P. thor Straten, and M. H. Andersen. 2013. Self-reactive T cells: suppressing the suppressors. Cancer Immunol. Immunother. 63: 313-319.

  3. Lyngaa, R., N. W. Pedersen, D. Schrama, C. A. Thrue, D. Ibrani, O. Met, P. thor Straten, P. Nghiem, J. C. Becker, and S. R. Hadrup. 2014. T-cell responses to oncogenic Merkel cell polyomavirus proteins distinguish Merkel cell carcinoma patients from healthy donors. Clin. Cancer Res. 20: 1768-1778.

  4. Gang, A. O., T. M. Frosig, M. K. Brimnes, R. Lyngaa, M. B. Treppendahl, K. Gronbaek, I. H. Dufva, P. thor Straten, and S. R. Hadrup. 2014. 5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies. Blood Cancer J. 4:e197. doi: 10.1038/bcj.2014.14.:e197.