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As part of this process, instead of fighting disease, immune cells.

Post-Doctoral Fellows in Immunoncology in Professor Jeffrey Pollard’s laboratory at the University of Edinburgh

The Pollard lab is seeking to recruit at least two new post-doctoral fellows to investigate the roles of myeloid cells in the regulation of anti-tumoural immune responses in cancer. These studies will be in mouse and human cancers using novel models to explore immune regulation.

The Pollard lab is well known for their studies in the tumour microenvironment. Using genetic models they were the first to show that tumour associated macrophages (TAMs) regulated tumour progression and metastasis. Subsequent studies showed TAMS enhance malignancy at the primary site by stimulating angiogenesis, inducing tumor cell migration, invasion and intravasation (1). At metastatic sites macrophages promote tumor cell extravasation, survival and subsequent growth and by suppressing anti-tumor immunity (2) Recent work has defined immunoregulatory roles for macrophages with suppression of both CD8+T cells and NK cells in mouse models (3). In addition to studies in mice, we have also defined TAMs in human breast and endometrial cancer and defined, using a novel model of IPSC derived macrophages (IPSCMacs) signaling pathways that are prognostic for poor disease specific survival (Cancer Cell 2019 In Press).

One post-doc will use a novel immune reported mouse strain that we have generated that allows definition of immune responses in vivo as well as conditional genetics to confirm function of the immunoregulatory mechanisms. The other post-docs will focus upon discovery projects in human monocytes and TAMs using our novel iPSC-Mac model to define function followed by experiments to explore mechanisms in humanized and GEM models of cancer. Cancers to be studied include breast cancers and their metastases as well as glioblastoma and ovarian cancer.

Key recent references:

1. Kitamura T, Qian BZ, & Pollard JW (2015) Immune cell promotion of metastasis. Nature reviews. Immunology 15(2):73-86.
2. Noy R & Pollard JW (2014) Tumor-associated macrophages: from mechanisms to therapy. Immunity 41(1):49-61.
3. Cassetta L & Pollard JW (2018) Targeting macrophages: therapeutic approaches in cancer. Nat Rev Drug Discov. 17: 887- 904

Contact Prof Jeff Pollard at jeff.pollard@ed.ac.uk with a cv and names of at least two referees.